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Article
December 8, 1928

SERUM PROPHYLAXIS IN A MEASLES EPIDEMIC

JAMA. 1928;91(23):1786-1792. doi:10.1001/jama.1928.02700230026008
Abstract

Renewed interest in the problems connected with measles has been steadily increasing in the last ten years. It may be said to have begun with the inconspicuous publication by Nicolle and Conseil1 in 1918. In the last five or six years particularly there have appeared numerous reports on the results of treatment with convalescent serum and many studies dealing with researches on the etiology and on the production of prophylactic and therapeutic serums. At the same time, epidemiologists have been pointing out that the general measures used in the effort to control epidemic diseases have been of little avail in measles, and they have emphasized the need of administrative methods based on exact knowledge of the natural history of the disease.2

REVIEW OF RECENT WORK ON MEASLES  Smallpox and diphtheria are the best examples of control by vaccination and active immunization. Similar methods have recently been attempted for

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