Recently we1 reported that the so-called fraction G of Cohn, Minot and their associates2 was found to be suitable for intravenous injection into patients with pernicious anemia. We have recently discovered that excellent remissions can be obtained in patients with low red blood cell counts from a single intravenous injection of as little material as the extract derived from 20 Gm. of liver. Since the effectiveness of fraction G was demonstrated to be many times greater when given intravenously than when given by mouth,1 the method appeared to be of practical value in the treatment of very sick patients or in those requiring unusually large dosage of effective principle by mouth. Certain immediate effects due to the presence of blood pressure lowering substances were readily controlled by injecting the material slowly. However, delayed reactions, sometimes of an unpleasant but apparently harmless character, occurred in about a third
STRAUSS MB, TAYLOR FHL, CASTLE WB. INTRAMUSCULAR USE OF LIVER EXTRACT: MAXIMAL RESPONSES OF RETICULOCYTES FROM DAILY INTRAMUSCULAR INJECTION OF EXTRACT DERIVED FROM TEN GRAMS OF LIVER: PRELIMINARY COMMUNICATION. JAMA. 1931;97(5):313–314. doi:10.1001/jama.1931.02730050021008
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