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June 19, 1943


JAMA. 1943;122(8):509-510. doi:10.1001/jama.1943.02840250033014

The metabolism of normal tissues is carried on by enzymic catalysis of definite patterns. These patterns may be disturbed by various causes, e. g. nutritional deficiencies, toxic actions and tumors. In the biochemical approach to the cancer problem tumor enzymology1 is receiving closer and closer systematic attention. Comparisons are made of the enzymic activities of neoplastic, mostly cancerous, tissue and of the normal tissues of origin; also of enzymic processes of normal animals and of tumor-bearing animals.

Greenstein,2 in a comprehensive review of work on tumor enzymology, emphasizes that "no simple generalization covers the enzymatic behavior of all or any one group of tumors," certain statements to the contrary notwithstanding. The range of enzymic activity in hepatoma, in lymphoma and in mammary and other tumors in mice on the whole is narrower than in the normal tissues of the sites of origin of these tumors, owing, it may