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June 19, 1943


JAMA. 1943;122(8):559. doi:10.1001/jama.1943.02840250083022

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To the Editor:—  In the March 6 issue of The Journal, Taylor and Page report on the use of typhoid shock therapy in 2 cases of renal disease, malignant hypertension and the nephrotic phase of chronic glomerulonephritis. From their results they conclude that this method of therapy is quite dangerous because of the evidence of severe renal irritation.From their protocols one might possibly draw somewhat different conclusions. The doses of triple typhoid vaccine used in the case of malignant hypertension appear to be somewhat too high for a first dose. The use of a second dose so soon after the first (which had already produced signs of renal irritation) complicates any conclusions one might draw. The second case is approached more cautiously and might be termed a minor triumph for shock therapy. Six intravenous injections of intravenous typhoid vaccine cured a case of chronic nephritis of over five months'

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