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This book presents a survey of the progress made in the field of creatine and creatinine metabolism during the last fifteen years, since the publication of Hunter's classic monograph on this subject. The author includes, where possible, applications of experimental studies to human metabolism and to certain diseases of man. Detailed instructions are given for the determination of creatine and creatinine in body tissues and fluids by standard procedures, and the newer specific enzymatic methods are briefly discussed.
The question of the precursors of creatine and creatinine in the organism is discussed in detail, the author defending at length his theory that creatine is formed primarily from aminoacetic acid and urea, with subsequent methylation, rather than from aminoacetic acid and arginine as is generally believed by other investigators. The author's finding of an apparent stimulation of creatine formation and creatinine excretion by a large number of widely dissimilar substances is
Creatine and Creatinine Metabolism. JAMA. 1943;122(8):570. doi:10.1001/jama.1943.02840250094034
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