In this country urinary tract infections are much more frequently seen and, in our malnourished, multiinfected patients, of a far more serious prognosis than literature would lead one to expect.1 The introduction of the sulfonamide compounds into the therapy of coliform group infections considerably improved the outlook. And yet the gravest of these cases, those showing a leukopenia, remained excluded from the beneficial and even life saving effect of this treatment, because of the clinical rule that a diminished number of leukocytes excludes the use of the sulfonamides. Such patients, being usually severely anemic and refractory to methenamine and pentose nucleotide, had a mortality of approximately 100 per cent, a fact to which the local difficulty of getting blood donors contributes. In the literature available here, only 2 cases of leukopenia and acute agranulocytosis were found2 in which, along with pentose nucleotides and blood transfusions, sulfathiazole was used
HEILIG R, VISVESWAR SK. MALIGNANT LEUKOPENIA SUCCESSFULLY TREATED WITH SULFAPYRIDINE. JAMA. 1943;122(9):591–594. doi:10.1001/jama.1943.02840260019005
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