[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
July 3, 1943


JAMA. 1943;122(10):677. doi:10.1001/jama.1943.02840270035014

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Students of the natural history of cancer in man were early impressed by the possibility that a hereditary factor might exist in its causation. The occurrence of numerous cancers, often of rare types, in certain families sometimes called cancer families, the similarities in type and in time of occurrence of tumors in identical or monochorial twins, the racial peculiarities in susceptibility and resistance to some kinds of cancer and the tendency for some persons to develop more than one primary tumor, seen especially in those who had been cured of one cancer, were suggestive of hereditary influence.

Further investigation was made largely by geneticists who entered the field in the first decade of the present century. Their studies were almost entirely on laboratory animals, especially mice. Large, long range research projects, some of which are still under way, were begun by Tyzzer, Lathrop, Little, Slye, Strong and others. It is

First Page Preview View Large
First page PDF preview
First page PDF preview