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To the Editor:—
The editorial comment regarding the use of sulfathiazole locally in the nose, pharynx, and larynx (The Journal, May 15, p. 180) prompts me to suggest that a word of caution is in order. In the course of certain experiments that we were carrying out it became desirable to test the capillary network of the lung as an absorptive surface for drug administration. This was done first by using atomized mists from suspensions of various sulfonamides, with resulting high blood levels of the drug (Harris, T. N.; Sommer, Harriet E., and Chapple, C. C.: Am. J. M. Sc.205:1 [Jan.] 1943).Certain disadvantages of the mists prompted the trial of dry sulfonamide powders as smokes from specially designed, though very simple, blowers. This work is being reported in the American Journal of the Medical Sciences in detail, but one of the results should be mentioned here, namely
Chapple CC. USE OF SULFATHIAZOLE LOCALLY IN OTOLARYNGOLOGY. JAMA. 1943;122(10):695. doi:10.1001/jama.1943.02840270053027
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