Recently we had an opportunity to study four brothers in a family each disabled by a disorder of the lower extremities characterized by (1) exaggerated callus under the great toe, insidious in appearance; (2) progressive ulceration at the site of the callus, eventuating in amputation at various levels, and (3) anesthesia of varying extent in the part involved.
The condition reported herewith is variously known as familial neurotrophic osseous atrophy,1 status dysraphicus,2 myelodysplasia3 and syringomyelia.4 No definite causative agent has been disclosed. In the cases under discussion the familial background is striking. Four male siblings and three male relatives have similar, if not the same, disease.
All the members of the family investigated were born in Scotland. The father of the four men who now have the disease died at the age of 52 of "paralysis following sleeping sickness." He is not known to
Mueller CR, Sugar SJ. FAMILIAL SYRINGOMYELIA. JAMA. 1943;122(11):743–744. doi:10.1001/jama.1943.72840280001008a
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