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JAMA Clinical Guidelines Synopsis
May 16, 2017

Antithrombotic Therapy for Venous Thromboembolic Disease

Author Affiliations
  • 1Division of Consultative Medicine and Division of Preventive, Occupational and Aerospace Medicine, Mayo Clinic, Scottsdale, Arizona
  • 2University of Chicago, Chicago, Illinois
JAMA. 2017;317(19):2008-2009. doi:10.1001/jama.2017.1928

The estimated annual incidence of VTE, defined as DVT of the leg or PE, ranges from 104 to 183 per 100 000 person-years.1 Compared with those without VTE, the 30-year mortality risk is increased for survivors of an episode of VTE and for survivors of an episode of PE (64 vs 136 and 211 per 1000 person-years, respectively).2 In 2012, the ACCP released the ninth-edition guidelines for antithrombotic therapy and prevention of thrombosis.3 Since the publication of that guideline, there has been improved understanding of the diagnosis and prognosis of VTE. The addition of non–vitamin K oral anticoagulants (NOACs) has altered the landscape of treatment options. This update addresses the role for NOACs and provides new recommendations for management of subsegmental PE and treatment of cancer-associated VTE.