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July 17, 1943

Current Comment

JAMA. 1943;122(12):812. doi:10.1001/jama.1943.02840290032012

DETOXICATION BY LIVER EXTRACTS  In standardized and well controlled experiments on rats, Chamelin and Funk1 found that extracts of whole liver reduced toxic action of sulfanilamide injected intraperitoneally in toxic quantities (400 mg. per kilogram). The liver extract had the same effect on the toxic action of diethylstilbestrol in rats. They found also that in mice injected with a strain of Streptococcus hemolyticus the survival rate was higher when the sulfonamide was combined with liver extract than when the drug alone was given; in other words, the liver extract diminished the toxicity of sulfanilamide without impairing its bacteriostatic action. Others2 have found that whole liver or liver extracts counteract chronic intoxication by sulfonamide drugs. Whole liver extract apparently reduces the toxicity of two substances widely different in chemical structure and pharmacologic action. Both the evidence and the mechanisms by which these effects are secured invite further study.