That sulfonamide compounds in themselves are bacteriostatic rather than bactericidal agents in vitro is an established fact.1 The rapidly growing medical use of sulfonamide powders, ointments and solutions for topical application in superficial and deep wounds raises the question of the possibility of their becoming contaminated with pathogenic organisms not affected by the drugs.
Recent findings have shown some products so contaminated. Our experiments have led us to believe that serious contaminations do occur. Welch, Slóctun and Herwick2 have emphasized the necessity for sterilization of sulfonamide dusting powders since these powders were incapable of killing tetanus spores with which they were contaminated. Recently a report3 has come from England of the, death of a patient from tetanus following the postoperative use of powdered sulfapyradine in the abdomen.
FISHER CV, ACCOUSTI NJ, THOMPSON MR. BACTERIAL CONTAMINATIONS IN SULFONAMIDE OINTMENTS. JAMA. 1943;122(13):855–858. doi:10.1001/jama.1943.02840300015004
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