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Clinical Trials Update
May 23/30, 2017

Vitamin E and Selenium Fail to Prevent Dementia in Men

JAMA. 2017;317(20):2054. doi:10.1001/jama.2017.6078

Antioxidant supplementation with vitamin E and selenium, taken alone or in combination, was not associated with a decreased incidence of dementia in asymptomatic older men, according to a study published by JAMA Neurology. Oxidative stress has been implicated as an important mechanism in Alzheimer disease, spurring interest in the use of antioxidants to modify risk of cognitive decline and dementia.