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July 24, 1943


Author Affiliations


JAMA. 1943;122(13):892. doi:10.1001/jama.1943.02840300052022

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To the Editor:—  Dr. Lewis Dexter and his associates in a paper published in The Journal, May 15, enumerate a considerable number of factors which "toxemia is not primarily due to," among them overactivity of the posterior pituitary gland. The past three years have witnessed great clarification in this problem.Since 1918 I have advocated the tenet that, in the causation of the syndrome termed late toxemia of pregnancy, consideration of hyperdynamic posterior pituitary principles may bring us within measurable distance of the realities of the situation. In 1933 it was argued that a number of seemingly unrelated investigations have converged so that it may be reasonably concluded that toxemia represents disordered autonomic physiology as the result of undue posterior pituitary (pitressin) stimulation (Am. J. Obst. & Gynec.26:311 [Sept.] 1933). Efforts to identify in the blood an excess of the pressor-antidiuretic pituitary principle stirred much comment with denials

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