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July 24, 1943


Author Affiliations

Boston. Visiting Neurologist, Boston City Hospital.

Cincinnati. Attending Neurologist, Cincinnati General Hospital.

JAMA. 1943;122(13):892. doi:10.1001/jama.1943.02840300052024

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To the Editor:—  Will you enter our opinion as to diagnosis on the father and son described under the heading of "Familial Tuberous Sclerosis (Epiloia) Without Adenoma Sebaceum" in The Journal, June 12?From the data presented in this article it would seem to us that the entire clinical picture in case 1 could best be explained by the diagnosis of toxoplasmic encephalitis. This diagnosis is possibly applicable also in case 2, but in view of the absence of ocular abnormalities or widespread calcified lesions in the cerebrum there is insufficient evidence for this or any other diagnosis. There are several reasons why the diagnosis is of some moment in such cases, not the least of which is the fact that toxoplasmosis may lend itself to therapy rather better than tuberous sclerosis.

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