Recently Dick1 reported the recovery of a patient with bacterial endocarditis to whom a massive dose of sodium sulfadiazine was administered. This is a report of 4 cases in which similar therapy was employed.
A white woman aged 36 had been having fever daily for five weeks before her admission to the Hotel Dieu on Sept. 21, 1942, the highest temperature each day being from 101 to 103 F. One week before admission she had experienced sudden pain in the left infra-axillary region, aggravated by deep breathing. She gave no history of rheumatic fever or of preexisting heart disease.She was in good general condition. The blood pressure was 130 mm. of mercury systolic and 50 diastolic. The pulse approached a water hammer type. The heart was moderately enlarged. Blowing systolic and diastolic murmurs were audible over the base of the heart. The lungs were normal. The
HULL E, BAYLEY RH, HOLOUBEK AB. THE THERAPY OF BACTERIAL ENDOCARDITIS WITH MASSIVE DOSAGE OF SULFADIAZINE: REPORT OF FOUR CASES. JAMA. 1943;122(14):928–930. doi:10.1001/jama.1943.02840310020005
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