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July 31, 1943


Author Affiliations

Department of Surgery

Department of Medicine

The University of Chicago.

JAMA. 1943;122(14):966. doi:10.1001/jama.1943.02840310058022

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To the Editor:—  In the first editorial of the July 3 issue of The Journal attention is drawn to the report of Dunn, Sheehan and McLetchie of Glasgow on the specific necrosing action of alloxan, the ureide of mesoxalic acid, on the islet cells of the pancreas and convoluted tubules of the kidney in rabbits. We have confirmed these observations in rabbits and have observed animals which survive injections of alloxan and exhibit only transitory hyperglycemia. Dunn and his co-workers observed no survivals beyond five days.Furthermore we have observed the effects of alloxan injected intravenously in dogs. Doses of 200 to 500 mg. per kilogram are fatal in one hour to five days. Where death does not occur in a few hours there is first a hyperglycemia followed by hypoglycemia, and by the end of forty-eight hours a pronounced sustained hyperglycemia obtains. The blood nonprotein nitrogen is also definitely

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