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July 31, 1943


JAMA. 1943;122(14):967. doi:10.1001/jama.1943.02840310059026

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To the Editor:—  In a communication in The Journal, July 3, page 695, certain disadvantages arising from the local use of sulfonamide powders in otolaryngology are pointed out. The experiences which my associates and I have had with the powder-blower method of therapy have not revealed these disadvantages.Of 18 patients thus treated, only 5 showed the presence of the drug in their blood streams at the end of twenty-four hours. In none of these did the value exceed 0.9 mg. per hundred cubic centimeters. In addition, the patient must of necessity hold his breath during the treatment or the tracheal reflex will make it impossible to continue with the procedure. Therefore we feel that during treatment little, if any, of the powder is aspirated.

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