The five day treatment of early syphilis warrants special consideration at this time, for it has certain undeniable advantages. It apparently "cures" a majority of patients, it affords rapid control of infectiousness, it gives no opportunity for lapse in treatment and there is a considerable saving to the patient in both time and expense. An effective "speed-up" method of treatment is desirable at this time, for it may be anticipated from statistics of past wars and the experience of England in the last year that there will be a sharp increase in syphilis. The question of the safety of the method has been the greatest drawback to its general adoption, for the incidence of cerebral reactions, some fatal, far exceeds the recorded incidence of similar reactions from standard treatment. Proponents of the five day method suggest, however, that the reports of fatalities from conventional treatment are not a true reflection
RATTNER H. THE TREATMENT OF EARLY SYPHILIS: BY THE CONCURRENT ADMINISTRATION OF ARSENIC AND BISMUTH IN A PERIOD OF FIVE DAYS. JAMA. 1943;122(15):986–989. doi:10.1001/jama.1943.02840320004002
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