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JAMA Diagnostic Test Interpretation
June 6, 2017

JAK2 V617F Mutation Testing in Patients Presenting With Hepatic and Portal Vein Thrombosis

Author Affiliations
  • 1Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
  • 2Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
JAMA. 2017;317(21):2228-2229. doi:10.1001/jama.2017.2329

A 27-year-old woman with asthma and obesity recently underwent a laparoscopic cholecystectomy for presumed cholecystitis. One week later, she had new-onset ascites and diffuse abdominal pain. She was a current smoker, was taking oral contraceptives, and delivered a healthy infant (2.5 months prior). The patient was not jaundiced, but her abdomen was distended without rebound or guarding. An ultrasound of her right upper quadrant showed hepatic vein thrombosis that was confirmed by magnetic resonance imaging of the abdomen. A laboratory workup and bone marrow biopsy were performed (Table).

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