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Comment & Response
June 6, 2017

Measurement of Hemoglobin A1c in Patients With Sickle Cell Trait

Author Affiliations
  • 1Department of Pathology and Anatomical Sciences, University of Missouri, Columbia
JAMA. 2017;317(21):2237. doi:10.1001/jama.2017.4643

To the Editor Dr Lacy and colleagues1 examined data from 2 retrospective cohort studies to determine if there were important glucose-independent differences in hemoglobin A1c (HbA1c) between African Americans with and without sickle-cell trait (SCT). They observed a mean difference of 0.29% between the 2 groups despite equivalent mean fasting and 2-hour plasma glucose levels. The authors concluded that this difference could be clinically important, especially when physicians use HbA1c to diagnose prediabetes or diabetes.