To the Editor Dr Lacy and colleagues1 examined data from 2 retrospective cohort studies to determine if there were important glucose-independent differences in hemoglobin A1c (HbA1c) between African Americans with and without sickle-cell trait (SCT). They observed a mean difference of 0.29% between the 2 groups despite equivalent mean fasting and 2-hour plasma glucose levels. The authors concluded that this difference could be clinically important, especially when physicians use HbA1c to diagnose prediabetes or diabetes.
Rohlfing C, Hanson S, Little RR. Measurement of Hemoglobin A1c in Patients With Sickle Cell Trait. JAMA. 2017;317(21):2237. doi:10.1001/jama.2017.4643
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