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JAMA Clinical Evidence Synopsis
June 13, 2017

NSAIDs for Chronic Low Back Pain

Author Affiliations
  • 1Department of General Practice, Erasmus Medical Center, Rotterdam, the Netherlands
  • 2Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, the Netherlands
JAMA. 2017;317(22):2327-2328. doi:10.1001/jama.2017.4571

Clinical Question  Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with greater pain relief than placebo, other drugs, and nondrug treatments for patients with chronic low back pain?

Bottom Line  Compared with placebo, NSAIDs are associated with a small but significant improvement in pain and disability in patients with chronic low back pain, although this difference became nonsignificant when studies with high risk for bias were excluded. The associated benefits were smaller than the minimal clinically important difference.