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Comment & Response
June 13, 2017

Cognitive Function After Testosterone Treatment

Author Affiliations
  • 1Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland
  • 2Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington
  • 3Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia
JAMA. 2017;317(22):2335-2336. doi:10.1001/jama.2017.5245

In Reply Dr Martins and colleagues note that our definition of AAMI was broad with respect to the definition of subjective memory complaints and in the cutoffs used to exclude objective impairment in memory, the latter potentially resulting in inclusion of some men with mild cognitive impairment and dementia. Although our criteria may have resulted in inclusion of some men with mild cognitive impairment or early dementia and adjudicated diagnoses of cognitive status were not available, we found no evidence of associations between testosterone treatment and cognitive function in subgroups of men defined as AAMI. As we reported, there were no significant effects of baseline global cognitive function, measured by the Modified Mini-Mental State Exam (scores <90, 90-94, 95-100), on associations between testosterone treatment and cognition across all levels of baseline cognitive function. Furthermore, we found no significant associations between testosterone supplementation and cognitive function in men who did not meet study criteria for AAMI and were defined as normal for age.