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August 14, 1943


Author Affiliations

Ann Arbor, Mich.

From the Department of Pharmacology, University of Michigan Medical School.

JAMA. 1943;122(16):1083-1084. doi:10.1001/jama.1943.72840330014007

The use of thymus extract in the attempt to modify the oxytocic of posterior pituitary injection is by no means new. A preparation, "Thymophysin," was introduced in Europe about fifteen years ago with the claim that the contractions resulting from its administration differ from those which follow the use of posterior pituitary injection alone in being rhythmic rather than tonic. On this basis it was claimed that Thymophysin could be used with safety to stimulate weak pains in the first stage of labor and to shorten the duration of the second stage. In the publication1 in which this preparation was presented there was only the most limited evidence for such a modification of the action of posterior pituitary injection by thymus extract.

A thorough pharmacologic study of this preparation, and of the effect of thymus extract on the pressor and oxytocic actions of posterior pituitary injection was made by