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This book is not a systematic treatise on the chemistry of amino acids, peptides and proteins or even on the physical chemistry of these important substances. It deals with them from the limited point of view of the number and distribution of the electrical charges they bear and the "implications of their charged structure for their physical properties and their physicochemical interaction with other molecules." The field covered by the monograph was opened by the studies of Debye and Hückel on the interionic forces in electrolyte solutions and by the work of Bjerrum, who demonstrated that aliphatic amino acids, even in the isoelectric state, bear positively and negatively charged ionic groups, by virtue of which they react as zwitterionen, or dipolar ions. By applying these fundamental concepts to theoretical and experimental studies of amino acids, peptides and proteins, the authors and their associates have paved the way to new and
Proteins, Amino Acids and Peptides as Ions and Dipolar Ions. JAMA. 1943;122(16):1150. doi:10.1001/jama.1943.02840330096024
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