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"Animals preserve their constitutions and activities like themselves, within the limits of variation that characterize the normal, either by preventing disturbances from occurring, or by compensating for each actual and incipient departure from normal" (p. 479). Summarized with that statement, this monograph represents a quantitative study of the restoration of physiologic equilibrium after its disturbance. Drawing freely on published work from his own and other laboratories, while presenting also appropriate hitherto unpublished data, the author mathematically characterizes recovery from increments or decrements ("loads") of components such as water or heat. Relationships between variables are portrayed graphically, using, in many instances, quotients and coefficients in order to increase the number of variables represented on a single pair of axes. Chapters and sections are provided with valuable summaries, and the last chapter contains recapitulations that may be read with profit before one approaches the more specific and detailed presentations of experimental data.
Physiological Regulations. JAMA. 1943;122(16):1150. doi:10.1001/jama.1943.02840330096025
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