[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
August 14, 1943

Physiological Regulations

JAMA. 1943;122(16):1150. doi:10.1001/jama.1943.02840330096025

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


"Animals preserve their constitutions and activities like themselves, within the limits of variation that characterize the normal, either by preventing disturbances from occurring, or by compensating for each actual and incipient departure from normal" (p. 479). Summarized with that statement, this monograph represents a quantitative study of the restoration of physiologic equilibrium after its disturbance. Drawing freely on published work from his own and other laboratories, while presenting also appropriate hitherto unpublished data, the author mathematically characterizes recovery from increments or decrements ("loads") of components such as water or heat. Relationships between variables are portrayed graphically, using, in many instances, quotients and coefficients in order to increase the number of variables represented on a single pair of axes. Chapters and sections are provided with valuable summaries, and the last chapter contains recapitulations that may be read with profit before one approaches the more specific and detailed presentations of experimental data.

First Page Preview View Large
First page PDF preview
First page PDF preview