[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.232.62.209. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
August 28, 1943

MODIFIED PROTAMINE ZINC INSULIN: AN IMPROVEMENT ON STANDARD PROTAMINE ZINC INSULIN: COMPARATIVE STUDIES ON SIXTY-TWON DIABETIC PATIENTS

Author Affiliations

ST. LOUIS

From the Department of Internal Medicine, Washington University School of Medicine, the Barnes Hospital and the Washington University Clinics.

JAMA. 1943;122(18):1225-1231. doi:10.1001/jama.1943.02840350009002
Abstract

The protamine zinc insulin now generally employed has proved valuable in the treatment of diabetes, but it has become increasingly evident that for many diabetic patients it is not ideal for maintenance therapy. This paper is the report of clinical investigations with a new form of modified protamine zinc insulin which has revealed distinct advantages in a series of 62 patients.

The use of the slow acting standard protamine zinc insulin has permitted a reduction in the number of injections necessary in the great majority of cases of diabetes. It has also diminished the wide fluctuations in the blood sugar occurring with several daily injections of regular insulin. It was hoped that good maintenance therapy in nearly all cases of diabetes could be established with a single daily injection of protamine zinc insulin. This hope has not been realized. In the six years since its introduction in February 1937 much

×