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August 28, 1943

Current Comment

JAMA. 1943;122(18):1252-1253. doi:10.1001/jama.1943.02840350036010

ANTIBACTERIAL SUBSTANCES FROM ASPERGILLUS MOLDS  The remarkable effects of penicillin in certain bacterial infections have aroused interest in the production of antibacterial substances by fungi other than Penicillium notatum. Wiesner1 found that strains of Aspergillus clavatus produced a substance which had bacterial as well as bacteriostatic effects on organisms not attacked by penicillin. Waksman and his associates2 report the results of studies of antibiotic or antibacterial substances obtained from cultures of Aspergillus fumigatus and Aspergillus clavatus, isolated from soils, stable manure and composts. Grown in a glucose-nitrate medium A. fumigatus produces an extractable, crystallizable, antibacterial substance called fumigacin, which is active against gram positive bacteria but has only little effect on gram negative organisms or fungi. Aspergillus clavatus also produces an antibacterial substance on synthetic mediums. This substance is called clavacin. It differs from fumigacin both chemically and in its antibiotic actions, being almost as active against gram