The observations that epithelial tumors of the urinary bladder are often multiple and that they show a remarkable tendency to reappear after removal, under circumstances that make it unlikely that the new tumors are either recurrences or local implantation metastases, have suggested to many the possibility that this epithelium in some persons is subjected to strong carcinogenic factors. It is uncertain what these factors are in the majority of patients with bladder tumors. In a few the cancers are due to chemicals, probably exogenous in nature, which are being excreted in the urine, as has been known since Rehn1 in 1895 described tumors of the bladder in workers with aniline dyes. Possibly a few are induced by arsenic.2 The total number of aniline dye tumors of the bladder collected from the world's literature is over five hundred.3 They therefore constitute a real therapeutic problem. But of greater
BLADDER TUMORS AND URINARY CARCINOGENS. JAMA. 1943;123(1):37–38. doi:10.1001/jama.1943.02840360039012
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