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Article
September 4, 1943

SUBJECTIVE REACTION TO PROSTIGMINE IN TREATMENT OF POLIOMYELITIS

Author Affiliations

South Portland 7, Maine.

JAMA. 1943;123(1):54. doi:10.1001/jama.1943.02840360056024

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Abstract

To the Editor:—  The use of prostigmine in the treatment of poliomyelitis would seem to merit encouragement. Through circumstances explained below it was necessary to deal with the patient's subjective reaction to the drug, as well as with the objective findings.A white girl aged 19 years, admitted to the Maine General Hospital in Portland, Maine, on Oct. 6, 1942 with the diagnosis of poliomyelitis, received the Kenny treatment there. On November 14, when she left the hospital, she was able to walk with difficulty on crutches through a small room. She continued taking exercises as advised in the hospital, though she improved slowly. In April 1943 she was started on prostigmine bromide and thiamine hydrochloride. The doses used were 15 mg. of prostigmine bromide and 5 mg. of thiamine hydrochloride given orally three times a day. Since she lived 15 miles away and it was impossible to observe the

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