Outbreaks of epidemic diarrhea of newborn infants occurred in the fall of 1942 in Cleveland, Carlisle, Pa., Detroit, Toledo, Ohio, Dayton, Ohio, and Indianapolis.1 The disease is now appearing again in various parts of the Midwest. The disease is not new. It has occurred many times in the past in Europe as well as in this country.2 Infants afflicted are usually less than 1 month of age. Those weighing over 7 pounds (3.2 Kg.) are victims as well as smaller and premature infants. The latter suffer the greatest death rate. The onset of the disease may be sudden or insidious. In the former case the baby begins to pass frequent, watery, greenish yellow stools, vomits and has fever. It may be drowsy or irritable. The weight loss may be alarming, and dehydration within a few hours may be severe. Fluid replacement, blood transfusions, changes of feeding formulas or
TWYMAN AH, HORTON GR. TREATMENT OF EPIDEMIC NEONATAL DIARRHEA WITH SUCCINYLSULFATHIAZOLE. JAMA. 1943;123(3):138–140. doi:10.1001/jama.1943.02840380014004
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