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Article
September 18, 1943

URINARY EXCRETION OF BISMUTH FOLLOWING LARGE BUT NONFATAL DOSE OF BISMUTH SUBSALICYLATE

Author Affiliations

Cleveland; Medical Corps, Army of the United States

From the Department of Pharmacology and the Department of Dermatology and Syphilology, Western Reserve University School of Medicine.

JAMA. 1943;123(3):149. doi:10.1001/jama.1943.82840380003007b
Abstract

A single dose of 9 cc. of bismuth subsalicylate in oil containing 675 mg. of elementary bismuth was injected into the left buttock of a man aged 47. The injection site was incised on the following day and two cigaret drains were installed. The lack of drainage and the x-ray film indicated that the bismuth suspension had spread along the fascia. The subject was released twenty-eight days after the injection. During this period of observation he developed pigmentation and ulceration of the oral and pharyngeal mucosae, moderate fever, leukocytosis, albuminuria, and high levels of bismuth in the urine.

The bismuth in each of the twenty-four hour urine specimens was estimated by a method already described.1 A total of 245.89 mg. of bismuth was recovered in the sequence recorded in the table.

(The studies terminated when the patient's request for release was granted.)

The patient received a ninefold dose of

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