Ever since the classic studies of Chittenden and his co-workers at Yale University a quarter of a century ago, the problem of the proper quota of protein in the diet of man has agitated those persons who are concerned with practical nutrition. The actual experiments of the New Haven group tended to demonstrate that a marked reduction in the allowance of protein then current in the daily regimen could be tolerated without signs of what the clinician might term malnutrition and without indications of any decrease in well being. There were intimations, further, that the low-protein regimen ought to be actually advantageous to the individual. The reasons advanced are not cogent in the light of present-day information. They involved the idea of "sparing" certain organs, notably the liver and kidneys, from the physiologic work entailed in the catabolism of the unnecessary nitrogenous intake and the elimination of the consequent waste
THE PROTEIN QUESTION. JAMA. 1929;92(6):474–475. doi:10.1001/jama.1929.02700320044014
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