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Article
September 18, 1943

Diagnosis of Uterine Cancer by the Vaginal Smear

JAMA. 1943;123(3):178. doi:10.1001/jama.1943.02840380054035

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Abstract

This is a descriptive atlas of the cells in vaginal smears under various conditions, normal and pathologic, with special emphasis on the diagnostic value of such smears in carcinoma of the cervix and the fundus of the uterus. The preparation and staining of vaginal smears is described in detail. The procedure appears to be simple and suitable for routine use. The morphologic appearances on smears are excellently illustrated in eleven plates of drawings and photomicrographs, all in colors. "Patient and repeated search of multiple preparations by well trained microscopists is essential to success." It is pointed out by the authors that the vaginal smear cannot be depended on for the ultimate diagnosis of uterine carcinoma in the place of biopsy and microscopic sections. The evaluation of individual cells or small groups of cells is more difficult than of carcinoma in tissue sections. But recognition of carcinomatous cells in vaginal smears

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