Most physicians during recent years have given little attention to malaria. Their attitudes have reflected the steadily diminishing incidence of indigenous malaria in the United States. However, circumstances associated with the war have checked this apathy and have brought a realization of the many problems which malaria still presents, particularly in the tropics. The experimental study of human infections has been retarded by the high host specificity of their parasites; this has prevented transmission to laboratory animals. As a consequence analogous parasites of birds, and more recently of mammals, have been extensively utilized for laboratory studies. The value as well as the limitations of such parasites is exemplified by the work which led to Ross's fundamental discovery of the transmission of one species of avian parasite by a culicine mosquito and of his failure to infect mosquitoes of this group with human parasites. He did not achieve success in infection
MALARIA. JAMA. 1943;123(4):211–212. doi:10.1001/jama.1943.02840390031010
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