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Article
October 2, 1943

THE USE OF HUMAN FIBRINOGEN IN RECONSTRUCTIVE SURGERY

Author Affiliations

MC-V (S), U.S.N.R.; MC-V (S), U.S.N.R.

JAMA. 1943;123(5):279. doi:10.1001/jama.1943.82840400003006a
Abstract

The successful application of the principles involved in the use of human fibrinogen is thought of sufficient and timely interest to report at this time. Work on animals has proved that both bovine and human fibrinogen may be used to good advantage as a bridge for tissue regeneration. The present case report presents the successful use of this substance in the treatment of a human patient.

REPORT OF CASE 

History.—  P. B., a man aged 27, was injured by a high explosive fragment on Nov. 19, 1942, sustaining a laceration of the right thigh. He developed a foot drop with paresthesias over the outer aspect of the thigh and foot. A month later he complained of a severe burning pain in the foot. X-ray examination revealed a foreign metallic body in the soft tissues at the middle third of the thigh. On March 23, 1943 a small piece of

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