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Article
October 16, 1943

THE USE OF ESTROGENS IN THE TREATMENT OF PROSTATIC CARCINOMA

JAMA. 1943;123(7):417. doi:10.1001/jama.1943.82840420010009a

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Abstract

Relief from local symptoms of prostatic carcinoma and from metastases in soft tissues or in bone has been afforded by castration, administration of estrogens or a combination of the two methods of therapy. The results are shown, not only by symptomatic improvement, but by x-ray evidence of regression of metastases and by reduction of the acid phosphatase content of blood. The latter is a product of prostatic tissue metabolism. To date there is reason to question the really curative value of these types of therapy, but palliation is of value even though it may not do more than prolong life and comfort for several months. It is probable that the use of estrogenic materials for this purpose is safe. The benefits are recognized only in cases of carcinoma arising in prostatic tissue. Accordingly, the Council has adopted the following paragraph for insertion in the New and Nonofficial Remedies section "Overies":

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