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At the present time at least 90 per cent of the arsphenamine that is used by physicians is of the neoarsphenamine variety. The real advantages of this drug are that it does not require neutralization and that it may be somewhat less toxic. Regarding the last mentioned point, it should be remembered that results obtained in animal experimentation do not necessarily apply to man. There is more than one experienced physician who believes that the percentage of reactions following the use of the neutral drug is greater than that following the use of the older drug. Certainly my experiences both in the Georgetown Clinic and in private practice have been such. A survey of the literature shows that these experiences are not unique. It would seem that the chief reason for the increased sale of the drug has been the injudicious activity of the manufacturers. The advertising material and the
HAZEN HH. THE LOW THERAPEUTIC INDEX OF NEOARSPHENAMINE. JAMA. 1929;92(9):696–697. doi:10.1001/jama.1929.02700350004003
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