Bio-Dyne ointment has been publicly advocated for the treatment of burns.1 In recent articles in the lay press it has been claimed that burns so treated heal painlessly and with remarkable rapidity. It has been stated that the ointment contains substances which stimulate epithelial proliferation. These public claims have resulted in inquiries by many patients and often in the demand that Bio-Dyne be used by physicians. If Bio-Dyne ointment has these properties, it represents a truly remarkable advance in burn treatment. Since, however, we were unable to find in the medical literature any experimental or clinical support for these claims, we decided to study the effect of Bio-Dyne ointment on fresh wounds of experimental animals and man.
In order to test the epithelial growth stimulating effect of Bio-Dyne as compared with petrolatum, these ointments were applied to fresh wounds made by removing the epidermis with the Padgett dermatome. These
Hirshfeld JW, Pilling MA, Maun ME. THE USE OF BIO-DYNE OINTMENT FOR BURNS. JAMA. 1943;123(8):476. doi:10.1001/jama.1943.82840430003007a
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