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October 23, 1943


JAMA. 1943;123(8):503. doi:10.1001/jama.1943.02840430055020

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To the Editor:—  In the August 7 issue of The Journal in the article on "Wound Healing and Infection After Local Implantation of Sulfonamide Powder," by J. Albert Key, mention is made of an earlier paper of mine. I believe it would be well if I answered certain of the observations.Late in 1942 I published further observations in the Journal of Bone and Joint Surgery in which I pointed out that, among other things, larger amounts of sulfonamides were used topically in the earlier months than were necessary and that after the publication of my first report I began using smaller quantities. However, I feel that the larger amounts were not the only retarding factor in wound healing; that the application of the drug to the cutaneous edges of the wound was, if anything, more disadvantageous. Since my first publication I have used sulfanilamide topically in well over 400

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