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Comment & Response
July 25, 2017

Deep Brain Stimulation for Obsessive-Compulsive Disorder—Reply

Author Affiliations
  • 1Department of Psychiatry, University of California, San Francisco
  • 2Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut
  • 3Department of Psychiatry, University of Florida, Gainesville
JAMA. 2017;318(4):393. doi:10.1001/jama.2017.7873

In Reply In our clinical review, we presented deep-brain stimulation as an investigational method to address treatment-refractory OCD in adults. The majority of studies involving deep-brain stimulation among patients with OCD have been limited to open-label designs and relatively small sample sizes, both of which constrain generalizability and examination of robust predictors of clinical treatment response. Nonetheless, the growing literature on this method suggests that deep-brain stimulation may be an effective modality for patients who continue to suffer from debilitating OCD symptoms despite adequate trials of standard and less-invasive treatments.