The frequency of chronic infectious diseases of the bronchi and the limitations of the various medical measures used in their treatment would appear to justify an investigation of the possibilities of sulfonamide therapy, yet a review of the recent literature shows only a few brief references to this subject. Although the pathologic changes in many of these diseases are at least partially irreversible, it would seem logical that diminution in the infectional factor should result in improvement. Acquired bronchiectasis and chronic asthmatoid bronchitis are characterized in their earlier phases by impairment in the function of the bronchi and bronchioles; gross structural disease is in most cases a secondary development. The possibility of restoring normal structure and function by medical measures is not a likely one, but partial elimination of infection would be expected to have a favorable effect on the symptoms and on the natural course of the disease.
NORRIS CM. SULFONAMIDES IN BRONCHIAL SECRETION: THE EFFECT OF SULFONAMIDES IN BRONCHIECTASIS. JAMA. 1943;123(11):667–670. doi:10.1001/jama.1943.02840460001001
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