A 57-year-old man with a history of HIV disease, hyperlipidemia, and major depressive disorder presented to his primary care physician with depression and insomnia. His mood had been controlled with bupropion, 300 mg/d, for the past several years; however, the recent death of his husband led to increased hopelessness, insomnia, and decreased energy. Results of laboratory studies (thyroid-stimulating hormone, complete blood cell count, and metabolic profile) were unremarkable. His total score on the Patient Health Questionnaire 9 (PHQ-9) was 16 (Table 1).
Hirschtritt ME, Kroenke K. Screening for Depression. JAMA. 2017;318(8):745–746. doi:10.1001/jama.2017.9820
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