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Article
November 13, 1943

The Common Form of Niacin Amide Deficiency Disease: Aniacinamidosis

JAMA. 1943;123(11):732. doi:10.1001/jama.1943.02840460066035

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Abstract

"Aniacinamidosis" is proposed as the name of a disease which the author characterizes by the syndrome resulting from a deficiency of niacinamide as determined by an original "office study" of "more than 150 patients." No laboratory studies were made and no illustrations are included. The symptoms of the disease, as well as its pattern, are stated in detail. A symptom was not considered as characteristic of the disease unless it appeared in at least 30 of the patients studied, disappeared following niacinamide therapy, and reappeared on cessation of therapy. The book is valuable in that it lists the symptoms which may result from a niacinamide deficiency. However, neither the single symptoms listed nor the entire syndrome are sufficiently unique or characteristic for the disease to warrant a positive diagnosis on their presence in a patient. The book leaves the impression that niacinamide deficiencies are vastly more prevalent than generally believed

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