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November 20, 1943


Author Affiliations

Clearwater, Fla.

JAMA. 1943;123(12):789. doi:10.1001/jama.1943.02840470055024

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To the Editor:—  In The Journal of April 16, 1938 M. E. Black and I reported the first known case of human infection due to Bacillus violaceus manillae. In this report it was noted that no other organisms were ever found as contaminants in any of the lesions at any time. As these were large open lesions discharging for weeks, this struck me as unusual. I therefore conducted a series of experiments at the time and found that there was a strong bactericidal substance produced by B. violaceus manillae which killed other organisms and therefore prevented contaminations. I wrote to various institutions in the attempt to get help in further isolating the agent, as it was a problem of biologic chemistry as well as of bacteriology. Various pathologists were advised of my findings at the time in private communications, but no one indicated any interest in this phase of the

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