Parkinson disease (PD) has been described as one of the most complex syndromes encountered in clinical medicine. Long-term treatment with dopaminergic agents, the mainstay of therapy, necessitates constant recalibration and possibly additional pharmacological, behavioral, and surgical therapy. Numerous motor and nonmotor PD symptoms may complicate the diagnosis and present therapeutic challenges (Figure).
Okun MS. Management of Parkinson Disease in 2017Personalized Approaches for Patient-Specific Needs. JAMA. 2017;318(9):791–792. doi:10.1001/jama.2017.7914
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