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The rationale for aseptic protein injections in nephritis patients is furnished by the coordinate consideration of the pertinent pathologic and biologic facts. Nephritis is recognized as the result of a general and renal capillary toxicosis brought about in most instances by the action of toxins of bacterial origin. This conception explains not only the morphologic changes in the glomeruli and the appearance of blood in the urine but also the physiologic deficiencies of the nephritic kidney and of the intermediate structures.
It was ascertained by the experimental research work of Jaffe and Petersen of Chicago that bacterial toxins may materially deteriorate the constitution of the capillaries. This may lead either to a pronounced permeability of the capillary walls, permitting diapedesis of the red cells, or to rupturing of these blood vessels, causing hemorrhage by rhexis of variable degree.
The toxic harm to the endothelial cells concerned produces physiologic deficiencies in
KOLISCHER G. ASEPTIC PROTEIN SHOCK IN NEPHRITIS. JAMA. 1929;92(12):968–970. doi:10.1001/jama.1929.02700380026009
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