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March 23, 1929


JAMA. 1929;92(12):1005-1006. doi:10.1001/jama.1929.02700380063031

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To the Editor:  —In The Journal, Nov. 17, 1928, Armstrong critically reviewed an article of ours on the subject of "Intradermal Vaccination" (Am. J. Dis. Child.35:186 [Feb.] 1928).In 1922, we decided to admit smallpox patients directly to the wards of the Contagious Disease Hospital. Before such admissions took place, we knew that the percentage of takes with the older methods (scratch, scarification, and the like) was not high enough or not certain enough, at least in our hands, to allow the indiscriminate exposure of patients admitted as a routine to those with active smallpox. For that reason we tried the intradermal method. We reasoned that patients might not always have a resultant take but we always knew that they got a certain amount of potent vaccine injection. All vaccines were tested by the Paul method for potency before being used.In some of our experiments, we vaccinated

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