In Reply We agree with Dr Lauche and colleagues that in our pooled analysis, the comparison groups were heterogeneous. However, based on published data, we judged them to be far less heterogeneous with respect to their expected effectiveness on pain and function in patients with acute low back pain. The comparison groups included ones that were intended to be ineffective, proven to be ineffective, had no or inconclusive evidence about effectiveness, or evidence of, at best, modest effectiveness.
Paige NM, Morton SC, Shekelle PG. Spinal Manipulative Therapy for Low Back Pain—Reply. JAMA. 2017;318(9):866. doi:10.1001/jama.2017.8841
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