Among the contributions to our knowledge of metabolism resulting from studies of radioactive chemical elements, few are of greater clinical interest than determination of the method of elimination of zinc and of the gastrointestinal absorption of iron reported by Montgomery and his colleagues1 of the University of California and by Hahn and his co-workers2 of the University of Rochester.
In 1927 Drinker3 found that in cats long continued ingestion of zinc leads to fibrotic changes in the acinar portions of the pancreas, the islet tissues remaining unchanged. This suggested that the acinar portion of the pancreas is concerned in the metabolism of zinc. The increased use of protamine zinc insulin gave special interest to this observation. Montgomery studied the fate of intravenously injected radiozinc (Zn65) in dogs with biliary, duodenal and pancreatice fistulas. The injected dose was usually 1 microgram per kilogram of body weight, an
ABSORPTION AND EXCRETION OF RADIOACTIVE ZINC AND IRON. JAMA. 1943;123(15):971–972. doi:10.1001/jama.1943.02840500035012
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